Target Synonym: Tumor necrosis factor ligand superfamily member;D8Ertd;4-1BB ligand;4-1BBL;BAF;BL;BLyS;D8Ertd387;D8Ertd387e;member 13b;TAL;TALL1;TALL-1;THANK;Tnfsf13b;TNFSF20;Tnlg7a;tumor necrosis factor (ligand) superfamily;Tumor necrosis factor ligand superfamily member 9;zTNF;zTNF4;Cd137l;Cd157l;Ly63l;Tnfsf9;Ly63l;Tnfsf13b
Background: 4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In addition, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Immunogen: Recombinant Mouse TNFSF9 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:50-1:1000;FCM 1:25-1:100
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