Target Synonym: Car;RP23-195K;RCC-Associated Protein G;MN/CA;CAIX;CA-IX;Carbonic Dehydratase;MN;MN/CA9;RCC-Associated Protein G250;RP23-195K8.9;Car9;Ca9
Background: Carbonic Anhydrase (CA) catalyzes the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. Topics in the CA meeting (6th International Conference on the CAs, June 20‑25, 2003, Slovakia) ranged from use of CAs as markers for tumor and hypoxia in clinic, as nutritional supplement in milk, and as a tool for CO2 removal and mosquito control in industry. CA9, also known as membrane antigen MN and renal cell carcinoma (RCC)‑associated antigen G250, is a transmembrane enzyme expressed primarily in carcinoma cells. It is one of the best markers for hypoxia and for RCC. rhCA9 corresponds to the extracellular portion of human CA9.
Immunogen: Recombinant Mouse Carbonic Anhydrase IX/CAR9 protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: IHC-P 1:250-1:1000
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