Target Synonym: L3T;T-cell surface antigen T4/Leu;T-cell surface glycoprotein CD;L3T4;Ly-4;T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;Cd4;L3T4;CD4mut;p55
Background: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
Immunogen: Recombinant Mouse CD4 Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: ICC/IF 1:100-1:500;FCM 1:100-1:500
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