Description: IL-6 is a multifaceted cytokine pivotal in host defense, orchestrating immune and inflammatory responses. It's generated by T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, showcasing a wide array of biological functions. IL-6 promotes B cell differentiation and antibody production, collaborates with IL-3 in megakaryocyte development and platelet production, triggers the expression of hepatic acute-phase proteins, and governs bone metabolism. IL-6 communicates through the IL-6 receptor system composed of two chains: IL-6Rα and gp130. Notably, murine IL-6 lacks activity on Human cells, while both Human and murine variants are equally effective on murine cells. The recombinant Human IL-6 is a 20.9 kDa protein encompassing 184 amino acid residues.
Expression System: E. coli
Molecular Weight: 20.9 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: IL6
Protein ID: P05231
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