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Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)

Recombinant Human R-Spondin 1/RSPO1 Protein (His Tag)
Artikelnummer
ELSPKSH033007-50
Verpackungseinheit
50μg
Hersteller
Elabscience Biotechnology

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Special promotion: Enjoy a 10% discount on Elabscience recombinant proteins through September 30, 2025.
Promo code: ELABPQ3
No additional discounts available during this period.

Protein Tag: C-His

Uniprot: Q2MKA7

Accession: Q2MKA7

Background: RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.

Bio Acitivity: Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 1-10ng/ml.

Sequence: Ser21-Ala263

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 0.01 EU per μg of the protein as determined by the LAL method.

Calculated MW: 27.8 kDa

Observed MW: 40 kDa
Mehr Informationen
Artikelnummer ELSPKSH033007-50
Hersteller Elabscience Biotechnology
Hersteller Artikelnummer PKSH033007-50
Verpackungseinheit 50μg
Mengeneinheit STK
Methode Cell Culture
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