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Protein Tag: C-Fc
Uniprot: P41272
Accession: P41272
Background: CD27 , also known as TNFRSF7 , is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage , and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer , CD27 has been shown to play roles in lymphoid proliferation , differentiation , and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule , the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity , and meanwhile , plays a key role in regulating B-cell differentiation , activation and immunoglobulin synthesis.
Bio Acitivity: Not validated for activity
Sequence: Pro24-Arg182
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 42.4 kDa
Observed MW: 60 kDa
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