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Protein Tag: C-Fc
Uniprot: Q60943
Accession: Q60943
Background: Interleukin-17 receptor (IL-17R) , also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217) , is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors , this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections , selective against Candida. It is characterized by persistent and/or recurrent infections of the skin , nails , and mucous membranes caused by organisms of the genus Candida , mainly Candida albicans.
Bio Acitivity: Not validated for activity
Sequence: Ser32-Trp322
Purity: > 90% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 1.0 EU/mg of the protein as determined by the LAL method.
Calculated MW: 56.9 kDa
Observed MW: 80 kDa
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