Target Synonym: Mxi;MAPK;CSPB;MAP kinase MXI;MAX-interacting protein;Mitogen-activated protein kinase;MAPK14;CSBP;CSBP1;CSBP2;CSPB1;EXIP;Mxi2;PRKM14;PRKM15;RK;SAPK2A;p38;p38ALPHA;p38 MAPK;MAP kinase MXI2;MAX-interacting protein 2;Mitogen-activated protein kinase 14;CSAID binding protein;CSAID Binding Protein 1;CSAID-binding protein;Csaids binding protein;CSBP 1;CSBP 2;Cytokine suppressive anti-inflammatory drug-binding protein;MAP kinase 14;MAP kinase p38 alpha;MAPK 14;MAX interacting protein 2;Mitogen Activated Protein Kinase 14;Mitogen activated protein kinase p38 alpha;Mitogen-activated protein kinase p38 alpha;MK14;Mxi 2;p38 ALPHA;p38 MAP kinase;p38 mitogen activated protein kinase;p38alpha Exip;p38-α
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen: A synthetic phosphopeptide corresponding to residues around Thr180, Tyr182 of human Phospho-p38 MAPK.
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:10000;IHC-P 1:200-1:1000;ICC/IF 1:20-1:100
Calculated MW: 41 kDa
Observed MW: 40 kDa
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