Target Synonym: Krd;VEGF Receptor;Fetal liver kinase;Protein-tyrosine kinase receptor flk;Vascular endothelial growth factor receptor;sVEGFR;VEGF R;6130401C;FLK;CD309;FLK1;VEGFR;VEGFR2;VEGF Receptor 2;KDR;6130401C07;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;Krd-1;Ly73;Protein-tyrosine kinase receptor flk-1;sVEGFR-2;Vascular endothelial growth factor receptor 2;VEGF R2;VEGFR-2;KDR
Background: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Immunogen: A synthetic peptide corresponding to the residues around Tyr1175 of Human Phospho-VEGF Receptor 2
Buffer: 10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL protein protectant, 50% glycerol, pH 7.5
Dilution: WB 1:1000-1:10000
Calculated MW: 152 kDa
Observed MW: 280 kDa
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