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Encompassing Amino Acids: 67-406
Assay Conditions: Assay was performed using BPS's Renin Assay kit, cat. # 80211, following the recommended assay protocol.
Background: Renin is a protease that is synthesized by the kidneys. Renin catalyzes the hydrolysis of angiotensinogen to angiotensin I, which is converted to angiotensin II, a highly potent vasoconstrictor. Renin inhibitors have been used therapeutically in the treatment of hypertension (high blood pressure).
Description: Human Activated Renin (GenBank Accession No. NM_000537), amino acids 67 - 406 (end) with C-terminal HIS tag, MW=38.6 kDa, expressed in a mammalian expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 250 mM imidazole, and 20% glycerol.
Genbank: NM_000537
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: P00797
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Cho, M.J., et al., J Pediatr Endocrinol Metab. 2011; 24(11-12):1085 - 1087
2. Schnermann, J., et al., Kidney Int. 2012 Mar; 81(6): 529 - 538
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