Product Description: Resmetirom (MGL-3196) is a highly selective and orally active thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM. Resmetirom can be used for the study of noncirrhotic nonalcoholic steatohepatitis[1].
Applications: COVID-19-immunoregulation
Formula: C17H12Cl2N6O4
References: [1]Kelly MJ, et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. J Med Chem. 2014 May 22;57(10):3912-23.
CAS Number: 920509-32-6
Molecular Weight: 435.22
Compound Purity: 99.90
Research Area: Cardiovascular Disease; Endocrinology
Solubility: DMSO : 75 mg/mL (ultrasonic)
Target: Thyroid Hormone Receptor
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