Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
Purity: ≥98%
Formula Markup: C19H16N2OS
Formula Weight: 320.4
CAS Number: 1429192-00-6
Notes: Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways.{38929,38932} Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 µM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 µM in HeLa cells.{38932,38931} Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 µM, respectively).{38928} In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.{38932,38930}
Deutsch
English
