RGB-286638 (free base), CAS 784210-88-4

Product Description: RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.

Applications: Cancer-Kinase/protease

Formula: C29H35N7O4

References: [1]Cirstea D, et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75.

CAS Number: 784210-88-4

Molecular Weight: 545.63

Compound Purity: 98.87

Research Area: Cancer

Solubility: DMSO : 2.6 mg/mL (ultrasonic)/Ethanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)

Target: CDK;GSK-3;JAK;MEK

• Artikelnummer: MEXHY-15504A-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15504A-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK