Product Description: Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis[1][2][3].
Formula: C21H24O9
References: [1]Wei W, et al. Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. Int Immunopharmacol. 2017 Jan;42:185-194./[2]Tao L, et al. Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo. Int Immunopharmacol. 2017 Jun;47:38-46./[3]Hibasami H, et al. Induction of apoptosis by rhapontin having stilbene moiety, a component of rhubarb (<i>Rheum officinale Baillon</i>) in human stomach cancer KATO III cells. Oncol Rep. 2007 Aug;18(2):347-51.
CAS Number: 155-58-8
Molecular Weight: 420.41
Research Area: Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Target: Apoptosis;Reference Standards
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