Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-ß-D-ribofuranosyl-1,2,3,4,5-13C5-1H-1,2,4-triazole-3-carboxamide
Purity: ≥95%
Formula Markup: C3[13C]5H12N4O5
Formula Weight: 249.2
CAS Number: 1646818-35-0
Notes: Ribavirin-13C5 is intended for use as an internal standard for the quantification of ribavirin (Item No. 16757) by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.{29248,59186} Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 µg/ml).{59187} Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50 = 109.5 µM).{45843} Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.{59188} Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Deutsch
English
