Rilmenidine (hemifumarate) (Standard), CAS 207572-68-7

Rilmenidine (hemifumarate) (Standard), CAS 207572-68-7
Artikelnummer
MEXHY-100490AR-0
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MedChemExpress

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Product Description: Rilmenidine (hemifumarate) (Standard) is the analytical standard of Rilmenidine (hemifumarate). This product is intended for research and analytical applications. Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3].

Formula: C10H16N2O.1/2C4H4O4

References: [1]Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S./[2]Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180./[3]Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Hum Mol Genet. 2010;19(11):2144-2153.

CAS Number: 207572-68-7

Molecular Weight: 238.28

Research Area: Cancer; Cardiovascular Disease

Target: Adrenergic Receptor;Apoptosis;Autophagy;Imidazoline Receptor;Reference Standards
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Artikelnummer MEXHY-100490AR-0
Hersteller MedChemExpress
Hersteller Artikelnummer HY-100490AR-0
Verpackungseinheit Get quote
Mengeneinheit STK
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