Products from BPS Bioscience require a minimum order value above 400€
Encompassing Amino Acids: 669-1072(end)
Application: Useful for binding assays.
Assay Conditions: Assay was done according to CBL-B TR-FRET Assay Kit (BPS Bioscience #79575).
Background: RNF31, or RING finger protein 31, is an E3 ubiquitin ligase also known as HOIP (HOIL-1 Interacting Protein). This protein is a component of the linear ubiquitin chain assembly complex (LUBAC) and is understood to promote tumor growth via activation of the nuclear factor kappa B (NF-kB) pathway. Overexpression of RNF31 is linked to breast cancer, hepatocellular carcinoma, and melanoma. The development of RNF31 inhibitors, such as HOIPIN-8, and other drugs will improve cancer outlooks and expand our understanding of tumor progression and the NF-kB pathway.
Description: Recombinant human RNF31 (RING finger protein 31), encompassing amino acids 669-1072(end). This construct contains an N-terminal GST-tag followed by a PreScission Protease Cleavage Site. This protein was affinity purified.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 20 mM glutathione
Genbank: NM_017999.5
Purity: ≥70%
Storage Stability: >6 months at –80°C.
Tags: GST-tag
Target: RNF31
Uniprot: Q96EP0
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
Deutsch
English
