Product Description: Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.
Applications: Cancer-programmed cell death
Formula: C27H31BrFNO6
Citations: Cancer Res Commun. 2024 Jul 19./Cell Death Dis. 2021 May 13;12(5):482./Cell Rep. 2022 Dec 13;41(11):111827./ImmunoMedicine. 2022 Dec./Mol Med Rep. 2021 Dec;24(6):828./ACS Synth Biol. 2023 Feb 28./Cancer Cell. 2023 May 23;S1535-6108(23)00142-3./Mol Cell. 2021 Jul 1;81(13):2736-2751.e8./Nat Commun. 2023 Jul 17;14(1):4267./Oncotarget. 2017 Feb 28;8(9):14860-14875./Sci China Life Sci. 2021 May 27;1-21.
References: [1]Morand OH, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90./[2]Liang Y, et al. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells. Onco Targets Ther. 2016 May 30;9:3223-32/[3]Liang Y, et al. Cholesterol biosynthesis inhibitors as potent novel anti-cancer agents: suppression of hormone-dependent breast cancer by the oxidosqualene cyclase inhibitor RO 48-8071. Breast Cancer Res Treat. 2014 Jul;146(1):51-62./[4]Chuang JC, et al. Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse. Biochem Pharmacol. 2014 Apr 1;88(3):351-63.
CAS Number: 189197-69-1
Molecular Weight: 564.44
Compound Purity: 99.42
Research Area: Cancer
Solubility: DMSO : ≥ 55 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: Others
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