Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Purity: ≥98%
Formula Markup: C17H18FNO2S
Formula Weight: 319.4
CAS Number: 298690-60-5
Notes: Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM).{22051} It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).{22053}
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