Product Description: RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively[1].
Applications: Metabolism-sugar/lipid metabolism
Formula: C12H17N3O
References: [1]Florent G Revel, et al. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A/[2]Justin N Siemian, et al. Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behav Pharmacol. 2017 Oct;28(7):590-593.
CAS Number: 1048346-74-2
Molecular Weight: 219.288
Compound Purity: 99.48
Research Area: Metabolic Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Trace Amine-associated Receptor (TAAR)
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