(−)-Rolipram, CAS 85416-75-7

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Purity: ≥98%

Formula Markup: C16H21NO3

Formula Weight: 275.34288

CAS Number: 85416-75-7

Notes: (–)-Rolipram is a phosphodiesterase 4 (PDE4) inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme) and an enantiomer of (±)-rolipram (Item No. 10011132).{52638} It enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM). (–)-Rolipram (1-1,000 µM) inhibits TNF and INF-γ production in L1402 CD4+ encephalitogenic rat T cells.{52639} It inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs when used at a concentration of 1 µM.{52640} (–)-Rolipram inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg).

• Artikelnummer: CAY31111-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31111-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK