Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (3ß,5ß,14ß)-21,23-epoxy-24-norchola-20,22-diene-3,14,17-triol
Purity: ≥98%
Formula Markup: C23H34O4
Formula Weight: 374.5
CAS Number: 156722-18-8
Notes: Rostafuroxin potently inhibits binding of endogenous ouabain to the Na+/K+ ATPase (IC50 = 1.7 µM) through the Src-epidermal growth factor receptor (EGFR)-dependent signaling pathway.{33528} This blocks the ouabain-dependent increase in Na+/K+ ATPase activity. In cultured renal cells where the Na+/K+ ATPase is upregulated or has increased activity, rostafuroxin normalizes mRNA levels and Na+/K+ ATPase activity.{33530} At very low doses (1 and 10 µg/kg for 5-6 weeks) in Milan-hypertensive rats, it decreased the development of hypertension.{33531} In a Phase II clinical study, rostafuroxin did not reduce blood pressure in human patients at doses of 0.05-5.0 mg/d.{33532}
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