Target Synonym: NET;C20orf;dJ1057B;RPRD1B;C20orf77;CREPT;NET60;dJ1057B20.2;K-H;Kub5-Hera
Background: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN2B or cyclin-A. Promotes cell proliferation.
Immunogen: Recombinant Human RPRD1B Protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
Calculated MW: 37 kDa
Observed MW: 37 kDa
Deutsch
English
