Product Description: RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels[1][2].
Applications: Cancer-programmed cell death
Formula: C21H13ClF6N2O5S
References: [1]Masashi Ohmi, et al. Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8./[2]Yoshihiko Okamoto, et al. Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol. 2012 May;40(5):1431-40.
CAS Number: 1254205-52-1
Molecular Weight: 554.85
Compound Purity: 99.84
Research Area: Cancer; Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: TRP Channel
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