Product Description: Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C26H26ClN3
Citations: Biomed Pharmacother. 2024 Jun 4:176:116826./Pharmaceutics. 2020 Jun 8;12(6):525.
References: [1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21./[2]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631./[3]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.
CAS Number: 158876-82-5
Molecular Weight: 415.96
Compound Purity: 99.70
Research Area: Inflammation/Immunology
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Autophagy;Histamine Receptor
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