Product Description: (S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1]. (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Formula: C27H34N4O5S
References: [1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
CAS Number: 2098799-78-9
Molecular Weight: 526.65
Compound Purity: 99.48
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Ligands for E3 Ligase