S49076 (hydrochloride), CAS 1265965-19-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-[[(3Z)-2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedione, monohydrochloride

Purity: ≥98%

Formula Markup: C22H22N4O4S / HCl

Formula Weight: 475.0

CAS Number: 1265965-19-2

Notes: S49076 is a multi-kinase inhibitor.{67829} It inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively). S49076 inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and 50s = 50-200 nM). In vivo, S49076 (6.25-50 mg/kg) reduces mean tumor volume in GTL-16 and U87MG mouse xenograft models.

• Artikelnummer: CAY41173-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41173-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK