Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride
Purity: ≥98%
Formula Markup: C23H32N2O2 / 2HCl
Formula Weight: 441.4
CAS Number: 165377-44-6
Notes: SA 4503 is a sigma-1 (σ1) receptor agonist that is selective for σ1 over σ2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively).{45146,45147} SA 4503 (10 μM) reduces light-induced cell death, decreases in σ1 expression, disruption of the mitochondrial membrane potential, and activation of caspase-3/7 in murine 661W cells, effects that are blocked by the σ1 receptor antagonist BD 1047 (Item No. 22928).{45147} In vivo, SA 4503 (10 mg/kg) increases extracellular acetylcholine concentrations in the frontal cortex and improves step-through latency in a passive avoidance test in rats with scopolamine-induced memory impairment.{45148} SA 4503 reduces working and reference memory errors induced by a time delay and MK-801 (Item No. 10009019) in a radial arm maze in rats when administered at a dose of 0.3 mg/kg, effects which are ameliorated by the σ1 antagonist NE-100 (Item No. 19642).{45149} Pre-administration of SA 4503 (500 μM) into the intravitreal space reduces light-induced thinning of the mouse retina outer nuclear layer by approximately 50%. {45147}
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