Product Description: SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C14H16N2O2
References: [1]L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83./[2]Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59./[3]Puzhong Lu, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020 Aug 4;6(1):51.
CAS Number: 923359-38-0
Molecular Weight: 244.29
Compound Purity: 99.60
Research Area: Metabolic Disease
Solubility: DMSO : 6 mg/mL (warming)
Target: ROCK
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