SAR441255 (sodium salt)

Shelf life (days): 1460.0

Formulation: A solid

Amino Acids: HXHGTFTSDLSKLK(γGlu-γGlu-palmitic acid)EEQRQXEFIEW

Purity: ≥95%

Formula Markup: C225H355N57O63 / XNa

Formula Weight: 4866.6

Notes: SAR441255 is a peptide triple agonist of the glucagon-like peptide 1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR).{67841} It induces cAMP accumulation in HEK293 cells expressing human GLP-1R, GIPR, or GCGR (EC50s = 1.03, 0.73, and 1.01 pM, respectively). SAR441255 (1-30 µg/kg) reduces body weight in a mouse model of high-fat diet-induced obesity. It also reduces body weight and blood hemoglobin A1c (HbA1c) levels in high-fat diet-induced obese diabetic cynomolgus monkeys when administered at a dose of 11 µg/kg.

• Artikelnummer: CAY41175-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41175-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK