Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine
Purity: ≥98%
Formula Markup: C17H15N9
Formula Weight: 345.36166
CAS Number: 1313725-88-0
Notes: Savolitinib is an inhibitor of c-Met (IC50 = 5 nM).{60305} It is selective for c-Met over a panel of 274 other kinases at 1 µM. Savolitinib inhibits c-Met autophosphorylation in NCI H441 human non-small cell lung cancer (NSCLC) cells (IC50 = 3 nM). It also inhibits proliferation of NCI H441 cells induced by HGF (Item No. 32052; IC50 = 6 nM) and in a panel of gastric cancer cells with dysregulated c-Met (EC50s = 0.6-14.7 nM).{60305,60306} Savolitinib (3 mg/kg) inhibits intratumor c-Met autophosphorylation by 94% and reduces tumor growth in an Hs 746T human stomach cancer mouse xenograft model.{60306}
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