Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol, monohydrochloride
Purity: ≥98%
Formula Markup: C20H14FN3O / HCl
Formula Weight: 367.8
CAS Number: 350228-36-3
Notes: SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively.{21464,12847} When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases such as ERK and JNK.{12847} It directly binds to the ATP binding pocket of p38 MAP kinases.{15221} SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.{21463,21466,21467}
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