SB 218078, CAS 135897-06-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione

Purity: ≥98%

Formula Markup: C24H15N3O3

Formula Weight: 393.4

CAS Number: 135897-06-2

Notes: SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM.{31189} It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 µM.{31189,29520} SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan (Item No. 14129).{31189} In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.{24026}

• Artikelnummer: CAY13335
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13335-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK