Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N2-[2-(2,2-diphenylethoxy)acetyl]-L-arginine, 2,2,2-trifluoroacetate
Purity: ≥95%
Formula Markup: C22H28N4O4 / CF3COOH
Formula Weight: 526.505629
CAS Number: 1140525-25-2
Notes: The anaphylatoxin C3a induces a range of responses by activating its G protein-coupled receptor, C3aR, resulting in calcium mobilization.{25900} SB 290157 is a non-peptide antagonist of C3aR, competitively blocking C3a binding with an IC50 value of 200 nM.{25894} It potently inhibits a wide variety of C3a-induced responses in cells, including calcium increase in human neutrophils (IC50 = 28 nM) and ATP release from guinea pig platelets (IC50 = 30 nM).{25894} SB 290157 is also effective in vivo, reducing inflammation in a variety of animal models.{25894,25897,25895} It also significantly reduces or reverses diet-induced obesity in rats and accelerates the mobilization of hematopoietic progenitor cells to the peripheral blood in mice.{25896,25898} Notably, SB 290157 has C3aR agonist activity in some cell systems.{25893,25899}
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