SB-431542, CAS 301836-41-9

SB-431542, CAS 301836-41-9
Artikelnummer
MEXHY-10431-10
Verpackungseinheit
10 mg
Hersteller
MedChemExpress

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Product Description: SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways[1][2][3].

Applications: Cancer-Kinase/protease

Formula: C22H16N4O3

References: [1]Gareth J Inman, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74./[2]Sunil K Halder, et al. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May;7(5):509-21./[3]Yi-qin Xiao, et al. SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1698-706.

CAS Number: 301836-41-9

Molecular Weight: 384.39

Compound Purity: 99.85

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL/Ethanol : 11.17 mg/mL (ultrasonic;warming)

Target: Apoptosis;Organoid;TGF-β Receptor
Mehr Informationen
Artikelnummer MEXHY-10431-10
Hersteller MedChemExpress
Hersteller Artikelnummer HY-10431-10
Verpackungseinheit 10 mg
Mengeneinheit STK
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