Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-1H-1,4-diazepine
Purity: ≥95%
Formula Markup: C21H28N2O8S2
Formula Weight: 500.5877
CAS Number: 447410-57-3
Notes: SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor).{45338} It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.