Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2'-O-methyl-P(S)-[[[(1-methylethoxy)carbonyl]oxy]methyl]-P-thiouridylyl-(3'?5')-2'-deoxy-adenosine
Purity: ≥95%
Formula Markup: C25H34N7O13PS
Formula Weight: 703.6
CAS Number: 942123-43-5
Notes: An antiviral agent and a prodrug form of SB-9000; reduces replication of wild-type, lamivudine-resistant, or adefovir dipivoxil-resistant HBV in HepG2/2.15 cells (EC50s = 2.5, 2.1, and 2.8 µM, respectively); inhibits replication in genotype 1a or 1b HCV replicon cells (EC50s = 2.2 and 1 µM); decreases viability, migration and invasion, and the levels of STAT3 and phosphorylated STAT3 and increases the levels of DDX58 in HCT116 and SW620 cells at 80 µM; reduces hepatic levels of HBV DNA in HBV-infected mice at 100 mg/kg per day