SB590885, CAS 405554-55-4

Purity: >98%

Concentration: 1 mg

Molecular Weight: 453.54

CAS Number: 405554-55-4

Activity: SB590885 is another selective small-molecule inhibitor of the B-Raf kinase. It has been used to overcome the dependence of MAPK signaling and tumor cell growth on BRaf kinase activity. The inhibition of MAP kinase is one of the vital ways to get rid of un-wanted tumor growth. SB590885 also act as an angiogenesis inhibitor and it helps in the research studies of different important kinase pathways.

Effect: In melanoma and colorectal cancer cell lines with B-Raf V600E mutation an effective inhibition of cell proliferation was achieved by using SB590885 at concentrations that blocked ERK phosphorylation.

References: 1. Takle AK. et al. 2008. Bioorg Med Chem Lett. 18(15): 4373-4376. PMID: 18621524 2. Ahnstedt H. et al. 2011. BMC Neuroscience. 12: 5. PMID: 21223556 3. Theunissen T. W. et al. 2014. Cell Stem Cell. 15: 1-17. DOI: http://dx.doi.org/10.1016/j.stem.2014.07.002

Formula: C27H27N5O2

Solubility: DMSO

Stability and Storage: Stable at -20°C. Keep away from direct sunlight.

• Artikelnummer: CGSSM48-1
• Hersteller: Cell Guidance Systems
• Hersteller Artikelnummer: SM48-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK