SC-58125, CAS 162054-19-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole

Purity: ≥98%

Formula Markup: C17H12F4N2O2S

Formula Weight: 384.3

CAS Number: 162054-19-5

Notes: SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.{1299} When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.{3464} In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.{5498} It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.{6465}

• Artikelnummer: CAY70655-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 70655-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK