Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-2-pyrazinecarboxamide
Purity: ≥95%
Formula Markup: C23H31Cl2N7O
Formula Weight: 492.44422
CAS Number: 906805-42-3
Notes: A CXCR3 antagonist (Ki = 0.4 nM); selective for CXCR3 over a panel of 49 other receptors at 10 µM; inhibits CXCL9-, CXCL10-, or CXCL11-induced chemotaxis in hemagglutinin- and IL-2-activated primary human T cells at 10 or 100 nM; increases survival in combination with cyclosporin A in a rat model of GVHD at dose of 5 mg/kg twice per day; reduces tumor growth and CD8+ T cell tumor infiltration in a murine B16/F10 melanoma model; decreases hepatic Cxcr3, TBARS, and triglyceride levels and hepatic macrophage infiltration in a mouse model of MASH induced by a methionine- and choline-deficient diet at 10 mg/kg per day
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