SCH 900776, CAS 891494-63-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(3R)-3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine

Purity: ≥95%

Formula Markup: C15H18BrN7

Formula Weight: 376.3

CAS Number: 891494-63-6

Notes: Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. SCH 900776 is a functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM).{29242} In comparison, 18-fold and 500-fold higher concentrations of this compound are required to inhibit CDK2 and Chk2.{29242} At 5-50 mg/kg, SCH 900776 dose-dependently interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.{29242}

• Artikelnummer: CAY18131-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18131-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK