Clone Name: HMV336
Light Chain: Kappa
Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.
Go to Normal Tissue GalleryGo to Cancer Tissue Gallery
Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Positive Control: Appendix: A strong SDHA staining should be seen in epithelial cells and a weak to moderate staining should occur in lymphocytic cells.
Negative Control: SDHA staining should be absent in all cells of a tumor with known SDHA expression loss.
Specificity/Sensitivity: <b>Highly recommended for IHC-P in human tissues.</b>
Form: Liquid
Buffer (with preservative): PBS, 2% BSA, 20% Glycerol, 0.025% ProClin 300.
Concentration: 0.44 mg/ml
Background: This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Uniprot ID: P31040
Antigen Species: Human
Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human SDHA. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: succinate dehydrogenase complex flavoprotein subunit A
Deutsch
English
