Semagacestat, CAS 425386-60-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (2S)-2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide

Purity: ≥95%

Formula Markup: C19H27N3O4

Formula Weight: 361.4

CAS Number: 425386-60-3

Notes: Semagacestat is a potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively.{27630,27426} It also blocks Notch signaling (IC50 = 14.1 nM).{27426} Semagacestat modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion.{27630,27426} Although semagacestat does not improve cognitive status in humans, it is useful as a pan γ-secretase inhibitor for research purposes.{27426,27631}

• Artikelnummer: CAY16713-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16713-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK