Description of Target: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Immunogen: This SERPINA1(Short peptide from AAT) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 391-418 amino acids from the C-terminal region of human SERPINA1(Short peptide from AAT).
Key Reference: Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).
Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
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