SGC707, CAS 1687736-54-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea

Purity: ≥98%

Formula Markup: C16H18N4O2

Formula Weight: 298.3

CAS Number: 1687736-54-4

Notes: Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.{21260,20245} SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural Genomics Consortium (SGC), SGC707 avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits the methylation of histones in cells with an IC50 value below 1 µM.

• Artikelnummer: CAY17017-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17017-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK