SGI-7079, CAS 1239875-86-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-benzeneacetonitrile

Purity: ≥98%

Formula Markup: C26H26FN7

Formula Weight: 455.5

CAS Number: 1239875-86-5

Notes: SGI-7079 is an inhibitor of the receptor tyrosine kinase Axl.{38140} It inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively), decreases invasion, and halts the cell cycle in the G1 phase. SGI-7079 synergistically increases the potency of erlotinib (Item No. 10483) on EGFR inhibition.{38139} In a mouse xenograft model of non-small cell lung cancer, SGI-7079 dose-dependently inhibits tumor growth, an effect that is greater when used in combination with erlotinib.

• Artikelnummer: CAY20111-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20111-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK