Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-acetyl-L-tryptophyl-6-diazo-5-oxo-L-norleucine, 1-methylethyl ester
Purity: ≥95%
Formula Markup: C22H27N5O5
Formula Weight: 441.48048
CAS Number: 2079939-05-0
Notes: A prodrug form of 6-diazo-5-oxo-L-nor-leucine; decreases P493B lymphoma cell viability (EC50 = 10 µM); metabolized to DON in tumor tissues, but metabolized to an inactive metabolite in gastrointestinal tissues, in CES1-/- mice bearing EL4, MC-38, EO771, or 3LL tumors; reduces tumor size in EL4 tumor-bearing CES1-/- mice at 0.1, 0.3, and 1 mg/kg