SIRT7 inhibitor 97491, CAS 1807758-81-1

Product Description: SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

Applications: Cancer-programmed cell death

Formula: C15H12ClN3O

References: [1]Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.

CAS Number: 1807758-81-1

Molecular Weight: 285.73

Compound Purity: 98.03

Research Area: Cancer

Solubility: DMSO : 500 mg/mL (ultrasonic)

Target: Apoptosis;Sirtuin

• Artikelnummer: MEXHY-135899-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-135899-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK