Sirtinol, CAS 410536-97-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide

Purity: ≥98%

Formula Markup: C26H22N2O2

Formula Weight: 394.5

CAS Number: 410536-97-9

Notes: Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively.{15174} It does not alter HDAC1 activity.{15174} Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.{20764,20761,20763} In plants, sirtinol can be metabolized to 2-hydroxy-1-naphthoic acid, which activates auxin signaling and alters plant growth and development.{20765,20762}

• Artikelnummer: CAY10523-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10523-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK