Product Description: SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively.
Applications: Neuroscience-Neuromodulation
Formula: C22H26ClNO2
References: [1]Jinzenji A, et al. Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125(2):217-26./[2]Kreitzer MA, et al. Glutamate modulation of GABA transport in retinal horizontal cells of the skate. J Physiol. 2003 Feb 1;546(Pt 3):717-31./[3]Barakat L, et al. GAT-1 and reversible GABA transport in Bergmann glia in slices. J Neurophysiol. 2002 Sep;88(3):1407-19.
CAS Number: 85375-15-1
Molecular Weight: 371.90
Compound Purity: 99.70
Research Area: Neurological Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 20 mg/mL (ultrasonic)
Target: GABA Receptor
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